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Role of Th1/Th2 cytokines in the regulation of cellular and humoral immunity. IL6, probably secreted by activated macrophages (Mϕ) is able to polarise naive CD4+ T cells (Th0) to effector Th2 cells, by inducing the initial production of IL4 in CD4+ T cells. IL12 triggers the differentiation of Th1 cells. Th1 and Th2 cells are mutually inhibitory. RA and SLE are Th1 and Th2 driven diseases, respectively.
