Figure 5  .

Pharmacokinetics of MTX in adult rabbits. MTX (30 mg/kg body weight) was administered intravenously (n=3), or intramuscularly (n=5). Serial plasma samples were then obtained, and MTX concentrations measured fluorometrically. The MTX concentrations in the synovial fluid (SF) of the knee joints of the animals were determined 24 hours after intramuscular injection of 30 mg MTX/kg body weight (n=5), as described in methods. Symbols represent means and SEM of the indicated number of animals. Most error bars do not exceed the size of their respective symbol.