Figure 6  .

No significant effects of systemic MTX on PG synthesis or PG content of articular cartilage in adult rabbits. Rabbits were treated with MTX (30 mg/week/kg intramuscularly) or placebo, respectively, for 6 or 12 weeks, and effects on the PG metabolism of the cartilage of the femoral condyles were assessed as described in methods. Bars represent means and SEM of eight animals per group (treatment for six weeks), or 16 animals per group (treatment for 12 weeks). CS = chondroitin sulphate.