Table 2.
Analysis of CD40–TRAF2 interactions
| CD40-p1 residue | Area buried,* % | Putative H bonds
|
van der Waals
|
|
|---|---|---|---|---|
| CD40 atom | TRAF2 atom | TRAF2 residue | ||
| Tyr-249 | 26 | n/a | n/a | R448, P449, D450 |
| Pro-250 | 85 | n/a | n/a | F447, P449, F456, S467 |
| Ile-251 | 45 | N | G468: O | P470, S467, F410 |
| O | G468: N | |||
| Gln-252 | 61 | Nɛ2 | S453: Oγ | F410, I465, A466, S467 |
| Nɛ2 | S454: Oγ | |||
| Nɛ2 | S455: Oγ | |||
| Glu-253 | 83 | N | A466: O | F410, I465, A466 |
| Oɛ1 | A466: N | |||
| Oɛ2 | Y395: OH | |||
| Oɛ2 | R393: NH1 | |||
| Thr-254 | 28 | N | D399: Oδ1 | G400 |
| Oγ1 | D399: Oδ2 | |||
*
, % Solvent-accessible surface area buried on TRAF2 binding.