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Impact of sensory and sympathetic nerve fibres on inflammation in the synovial tissue. The diagram shows the balance of proinflammatory and anti-inflammatory mechanisms. Substance P of sensory nerve fibres and norepinephrine/adenosine at low concentrations seem to be proinflammatory, whereas norepinephrine/adenosine at high concentrations seem to be anti-inflammatory. α2 = alpha 2 adrenergic; β = beta adrenergic; A1 = adenosine receptor 1; A2 = adenosine receptor 2.
