Figure 3  .

Levels of tissue inhibitors of metalloproteinase (TIMP) inhibitory activity in media samples removed from cartilage cultures at day 14 after stimulation with interleukin 1α ( IL1α), oncostatin M (OSM), IL1α + OSM, with and without IL13. Cartilage was incubated and treated as described in fig 1. The levels of TIMP released into the medium on day 14 were measured and the results expressed as U/ml (mean (SD)). Student's unpaired two tailed t test was used to compare IL1α and IL1α + IL13, where †††p<0.001. The same test was used to compare IL1α + OSM with IL1α + OSM + IL13, where ***p<0.001.