Figure 4  .

Analysis of signal transduction pathways which play a part in mediating mast cell chemoattractant activity in synovial fluids. Mast cells were treated with (A) pertussis toxin, or (B) genistein for 90 minutes before chemotaxis assay. The fluids were used at dilutions giving optimal migration. Open bars = control; filled bars = with inhibitor. The results are from three experiments performed in triplicate. Results are given as means (SEM). A significant effect was obtained as indicated: **p<0.01, ***p<0.001.