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Schematic diagram of relation between inflammation and oxidative injury, and endogenous formation of 8-iso-PGF2α through free radical and 15-keto-dihydro-PGF2α via cyclo-oxygenase catalysed oxidation of arachidonic acid. ROS = reactive oxygen species; COX = cyclo-oxygenase; 15-PGDH = 15-hydroxyprostaglandin dehydrogenase, Δ13-reductase.
