Figure 1  .

Individual values of biochemical markers of bone, cartilage, and synovium turnover in 67 patients with knee OA. Each value is expressed as a Z score—that is, as the number of standard deviations from the mean of 67 healthy controls matched for age. *p<0.0001 v 0. S = serum; U = urine; OC = osteocalcin; CTX-I, CTX-II = types I and II collagen C-telopeptide, respectively; COMP = cartilage oligomeric matrix protein; YKL-40 = human cartilage glycoprotein 39; Glc-Gal-PYD = glucosyl-galactosyl pyridinoline; HA = hyaluronic acid; PIIINP = type III collagen N-propeptide; CRP = C reactive protein.