Figure 2.

Natural clinical course of arthritis in B6.IFNγ KO mice. The average clinical score of arthritic mice reflects the clinical severity of an individual arthritic limb and the number of affected limbs. DBA/1 mice exhibited a typical monophasic progressive disease. Similarly, B6.IFNγ KO mice showed a progressive type of arthritis. Most of the affected joints progressed from initial swelling to distortion and some affected joints progressed to ankylosis. The lower clinical score at the late stage of disease in B6.IFNγ KO mice reflects the smaller number of limbs affected and less severity of the affected limbs than in DBA/1 mice (*p<0.05). B6 mice had a mild and transient arthritis affecting only one limb in each arthritic mouse.