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. 2003 Oct;62(10):983–990. doi: 10.1136/ard.62.10.983

Figure 7.

Figure 7

Predominant TCR Vß6 and Vß8 usage in arthritic joints in B6.IFNγ KO mice. Expression of TCR Vß gene expression was determined by quantitative real-time RT-PCR. This composite graph shows individual arthritic mouse samples from both DBA/1 (top, n=9) and B6.IFNγ KO (bottom, n=12) mice. The Vß gene expression was expressed as a relative quantity in reference to the Cß expression in the same sample. In DBA/1 mice, Vß6 had a predominant expression over the other Vß genes in most of the samples. In B6.IFNγ KO mice, Vß6 had a two- to 50-fold increased expression over other Vß genes in 10 of 12 samples. In addition, the Vß8 gene family exhibited the second most increased expression in most Vß6 predominant samples. In the two samples in which Vß6 was not predominant, Vß8.1 and Vß8.2 outnumbered Vß6 as the predominantly expressed Vß genes.