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. 2003 Oct;62(10):991–994. doi: 10.1136/ard.62.10.991

Figure 2.

Figure 2

(A) Effect of specific H1 and H2 histamine receptor antagonists on the histamine stimulated proliferation of HAC. 1, Control culture; 2, + histamine (20 µmol/l); 3, + mepyramine (20 µmol/l); 4, + ranitidine (20 µmol/l); 5, + histamine (20 µmol/l) and mepyramine (20 µmol/l); 6, + histamine (20 µmol/l) and ranitidine (20 µmol/l). Note the significant inhibition of the histamine effect by mepyramine (*p=0.003, Student's t test). Representative experiment (n=3) using preparation HAC3, passage 2, this being qualitatively similar for HAC2 and 5. (B) Effect of α-FMH on the proliferation of HAC. 1, Control culture; 2, + histamine (20 µmol/l); 3, + α-FMH (100 µmol/l); 4, + α-FMH (100 µmol/l) and mepyramine (20 µmol/l). Representative experiment showing qualitatively similar data from two HAC cultures. Note modest reduction in proliferative rate of HAC by α-FMH (*p=0.05, Student's t test).