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"Total" MMP activity in joint extracts on day 3 of AIA. Total activity of MMP was determined by cleavage of the peptide MCA-Pro-Leu-Gly-Leu-DAP (DNP-Ala-Arg-NH2), resulting in an increase of fluorescence. Results are expressed as means (SEM) (n = 8 for each group). *p⩽0.05 in comparison with IgG treated controls.
