Figure 1.

 Protein production of MMP-1, MMP-3, TIMP-1, IL-6, and IL-8 by rheumatoid synovial fibroblasts (n = 5). Cells were stimulated with TNFα and/or IL-1ß for 48 hours and pretreated with a concentration range of RWJ 67657 (t = –1 h). Protein production was measured in supernatants by ELISA and expressed in ng/ml. unst, unstimulated; 0–10, concentration RWJ 67657 added. Bars show mean and SEM. *p<0.05, **p<0.001, Dunnett's post test, tested against the stimulated control. IL, interleukin; MMP, matrix-metalloproteinase; TIMP-1, tissue inhibitor of matrix-metalloproteinases; TNF, tumour necrosis factor.