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. 2004 Nov;63(11):1453–1459. doi: 10.1136/ard.2003.013011

Figure 2.

Figure 2

 mRNA expression of MMP-1, MMP-3, TIMP-1, and ADAMTS-4 in rheumatoid synovial fibroblasts (n = 3). Cells were stimulated with TNFα and/or IL-1ß for six and 24 hours and pretreated with a concentration range of RWJ 67657. mRNA expression was determined with real time RT-PCR (reverse transcriptase polymerase chain reaction) and results were expressed as -fold induction compared with unstimulated cells (fold induction = 1). White bars represent values after TNFα stimulation (scale on left vertical axis); grey bars represent values after IL-1ß stimulation and black bars after IL-1ß+TNFα stimulation (scale on right vertical axis). Bars represent means and SEM. *p<0.05, Bonferroni multiple comparison test, tested against the stimulated control. ADAMTS, a disintegrin and metalloprotease with thrombospondin-1 motif; MMP, matrix-metalloproteinase; TIMP-1, tissue inhibitor of matrix-metalloproteinases.