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LEF-M decreases the transendothelial migration of PBMC both in healthy subjects and patients with RA. In 14 experiments, EC and PBMC of healthy volunteers were preincubated with 100 µM LEF-M for 24 hours. A significant decrease in the percentage of migrated PBMC was found as compared with control experiments (17 (3)% v 7 (1)%, p<0.005).
