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Chronic inflammation—prophylactic administration: (A) knee joint swelling; (B) urinary NOx; and (C) PGE2, expressed as a percentage change compared with preinjection values in response to intra-articular injection of FCA. There was significant joint swelling and increased NOx and PGE2 production in the vehicle, L-NIL (43 mg/kg), and SC-236 (5.6 mg/kg) prophylactically treated groups. A non-inflamed, untreated group is included for comparison. Values represent means (SEM).
