Figure 5.

 Chronic inflammation—combined administration: Knee joint swelling, expressed as a percentage change compared with preinjection values in response to intra-articular injection of FCA. Combined administration of L-NIL (43 mg/kg) and SC-236 (5.6 mg/kg), (A) prophylactically or (B) therapeutically at days 9 and 14, respectively, as compared with untreated and vehicle treated controls. Data for independent administration of each of these drugs (from figs 2 and 3) are also included for comparison. Values represent means (SEM), n = 6/group. ***p<0.001 compared with untreated controls; ‡‡‡p<0.001 compared with vehicle treated inflamed animals; ††† p<0.001 compared with combination treatment inflamed animals (Bonferroni post hoc tests).