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STAT1 expression is raised in RA compared with OA fibroblast-like synoviocytes (top panel) and STAT1 tyrosine and serine phosphorylation are induced by stimulation with IFNß (second and third panels). Fourth passage RA and OA synoviocytes were treated with IFNß (250 U/ml). Cell extracts were prepared 30 minutes after cytokine stimulation, corrected for total protein content, and analysed by immunoblotting.
