Figure 6 .

Expression of chemokines and cytokines is up regulated after RAdMMP-13 injection Production of mRNAs for (A) MCP-1, (B) MCP-2, (C) MIP-1α, (D) RANTES, (E) TNFα, and (F) IL1ß mRNA production was measured in intact, RAdMMP-13, and RAdLacZ injected mouse knee joints (n = 5–6 per group) using a quantitative Taqman RT-PCR method. The results were normalised for a constant amount of 18S ribosomal RNA. For statistical analyses a Wilcoxson matched pair test was used: *p<0.05, **p<0.005 significance of mRNA levels in RAdMMP-13 treated knee joints over those injected with RAdLacZ.