Figure 1.

 (A) Incorporation of [³H]thymidine by PBMC of healthy donors and patients with RA after stimulation with LPS. Graph depicts the number of counts as measured after 24 hours of incubation in the presence of various concentrations of leflunomide (0–100 µmol/l). (B) Production of IFNγ (pg/ml) by PBMC after 36 hours. Depicted are controls and cells stimulated with PHA in the presence of various concentrations of leflunomide (0–100 µmol/l). (C) Production of IL6 (pg/ml) by PBMC after 8 hours. Depicted are controls and cells stimulated with PHA in the presence of various concentrations of leflunomide (0–100 µmol/l).