Figure 3.

Effects of TGFß1 on OSM+TNFα-induced ADAMTS aggrecanases. Bovine nasal or human articular chondrocytes were stimulated with OSM+TNFα (both at 10 ng/ml)±TGFß1 for 24 hours. Real time PCR was performed on isolated RNA, and the normalised results presented graphically as described in fig 2. No signal was detected for ADAMTS-8 in human chondrocytes with any treatment. The data shown are representative of two separate chondrocyte preparations.