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. 2005 Apr 20;64(12):1692–1697. doi: 10.1136/ard.2004.033753

Figure 1.

Figure 1

 The human hepatoma cell line Hil3, transfected with ISRE-Luc, responds to type I IFN stimulation in a dose dependent manner. Luciferase activity is measured in counts per second and is proportional to IFN activity as demonstrated by linear regression analysis (Graphpad Prism). All recombinant type I IFN subtypes tested show significant activity. Similarly, natural leucocyte IFN (multiple IFNα subtypes + IFNω) produces a robust luciferase response. In contrast, the Hil3 reporter assay exhibits a very weak response to type II IFN (IFNγ).