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Neutralising antibody (NAB) titres in serum after intra-articular (IA) injection of rAAV2 or rAAV5. Arthritic rats were injected with 1.14x1010 GC rAAV2 (A) or rAAV5 (B) into the right ankle joints. Serum samples were obtained 1, 2, 3, and 4 weeks after injection. Titres were calculated as the highest dilution which shows no decrease in number of ß-Gal positive cells compared with wells incubated with rAAV.LacZ alone.
