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Time course of IL18 effects on gene expression of MMP-1, MMP-3, MMP-13, and aggrecanase-2 in OA chondrocytes. (A) Representative results from chondrocytes that responded to IL18 by RT-PCR. (B) Expression level of aggrecanase-2 analysed by quantitative real time RT-PCR. The details are described in "Patients and methods". The copy number of aggrecanase-2 mRNA was standardised by the copy number of GAPDH mRNA. Compared with the control (without IL18): *p<0.05, **p<0.01.
