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Time course of mRNA expression in monocyte derived, macrophage-like cells in response to treatment with TNFα (50 ng/ml). Results are from three donors and expressed as GAPDH normalised REU as in the legend to fig.1. *p<0.05 from time zero by repeated measures ANOVA. (A) Cryopyrin message was induced in two phases, whereas (B) ASC levels fell. (C) Pyrin remained unaltered. (D) Cells were fully activated as indicated by continuous expression of IL1ß.
