Figure 4.
CD64-CaMi-induced macrophage apoptosis in time prevents CD3/CD28-induced T cell cytokine secretion (n = 3). SFMC were cultured with CD64-CaMi at a concentration of 10–8 mol/l and 10–9 mol/l or without CD64-CaMi for 3 days. After this, T cells were costimulated by CD3/CD28 for 24 hours, and IFNγ and TNFα levels were measured. *Significant inhibitions of T cell activity upon (pre-) treatment with CD64-CaMi compared with control cultures (p<0.05).