Figure 4.

Humoral hyporesponsiveness to p1–102 in CB6 F₁ mice receiving 1–102-IgG-transduced BM. CB6 F₁ mice were irradiated with 400 rad and injected with mock-transduced or F12.7 gene-transduced BM cells. Mice were primed and boosted with p1–102 and HEL. Left Y ordinate represents the IgG titer against p1–102, and the right Y ordinate represents the titers against epitopes. Antibody IgG titers against p1–102 and p73–88 in recipient mice of F12.7 transduced BM (filled columns) are significantly lower than those in mock controls (empty columns) (P < 0.05). Note that antibody against the minor epitope (p55–69) also is reduced in the recipient mice of F12.7-transduced BM.