Figure 2.

Sequence analysis of the protease-encoding region of primary HIV-1 isolated from seven heavily drug-experienced patients. Deduced amino acid sequences (from direct sequencing) of the protease of primary HIV-1 isolates obtained from seven heavily drug-experienced patients are shown. Amino acid sequences of the protease of molecular clones generated from HIV-1 isolated from patients 4, 6 and 7, also are shown. The fractions of clones containing indicated mutations are shown on the right. The consensus B sequence cited from the Los Alamos database (24) is shown at the top. Identity with this sequence at individual amino acid positions is indicated by dots. An asterisk indicates a stop codon.