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. 1999 Jul 20;96(15):8675–8680. doi: 10.1073/pnas.96.15.8675

Figure 3.

Figure 3

In vitro selection of HIV-1 variants resistant to KNI-272, JE-533, or JE-2147. HIV-1LAI or HIV-1NL4–3/I84V was passaged in the presence of increasing concentrations of KNI-272, JE-533, or JE-2147 in MT-2 cells. The selection was carried out for a total of 20–79 passages with compound concentrations ranging from 0.01 to 2.5 μM. Proviral DNAs from the lysates of infected cells from several passages were sequenced. Drug susceptibility of HIV-1 propagated in the presence of JE-2147, JE-533, and KNI-272 at passages 73, 32, and 51, respectively, is illustrated in Table 5.