Table 4.
Prenatal use of paracetamol by pregnant women and risk of miscarriage. Values are numbers (percentages) unless stated otherwise
|
Miscarriage
|
|||
|---|---|---|---|
| Paracetamol use* | Yes (n=141) | No (n=793) | Hazard ratio (95% CI)† |
| Non-users (n=762) | 117 (15) | 645 (85) | 1.0 |
| Users (n=172): | 24 (14) | 148 (86) | 1.2 (0.8 to 1.8) |
| Gestational age at first use: | |||
| At conception (n=19)‡ | 2 (11) | 17 (89) | 0.8 (0.2 to 3.3) |
| After conception (n=147) | 21 (14) | 126 (86) | 1.2 (0.8 to 2.0) |
| Duration of use: | |||
| ≤1 week (n=147) | 22 (15) | 125 (85) | 1.3 (0.8 to 2.1) |
| >1 week (n=23) | 2 (9) | 21 (91) | 0.7 (0.2 to 2.9) |
*
NSAID or aspirin users were excluded from this analysis.
†
Adjusted for previous miscarriage, education, maternal age, gravidity, race, use of Jacuzzi or hot tub, multivitamin use, and smoked since last menstruation. Further adjustment for other variables listed in table 1 did not change the results.
‡
Within the first week of gestational age.