Figure 3.

Micrographs of striatal sections prepared from brains 14 days after intrastriatal quinolinic acid injection, processed for DARPP-32 immunohistochemistry (A, B, E, and F) or cresyl violet staining (C, D, G, and H). Sections from wild-type mice (wt; A, C, E, and G) show massive loss of DARPP-32- and cresyl violet-stained cells. Sections from transgenic mice (tg; B, D, F, and H) reveal only a minor loss of DARPP-32- positive neurons (B and F) and an increased number of cresyl violet-stained cells (D and H) along the cannula track (arrowheads). [Bar = 1.0 mm (A–D) and 50 μm (E–H).]