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Flow-induced vasodilation was attenuated by oxyHb in a dose-dependent manner. Vasodilatory response to the increased flow was completely abolished by 10 μM oxyHb, identical to that of NOS inhibitor l-NMMA (10 μM). n = 5, basal diameter = 74 ± 4 μm; maximum diameter = 112 ± 3 μm; ∗, P < 0.05, all interventions versus control.
