Figure 2 .

Effect of pH on large conductance K⁺ channel activity in isolated surface cells from rat distal colon. P_o was determined over a range of V_com values using inside-out patches from distal colonic surface cells isolated from K⁺ loaded animals (K₂SO₄ solution containing 32 nM Ca²⁺ in bath, K₂SO₄ solution containing 1.2 mM Ca²⁺ in the pipette). Data at pH 7.40, 7.60, and 8.00 were obtained from five to eight patches. *p<0.05, **p<0.01, and ***p<0.001 compared with value at pH 7.40. NS, not significant compared with value at 7.40.