Figure 1  .

Experimental protocols for study A (dose-response study) and study B (cholecystokinin (CCK)-A receptor blockade). To determine the relationship between the lipid dose administered and severity of dyspeptic symptoms, six patients were studied on three occasions each, receiving duodenal infusion of 0.9% saline, or 10% or 20% lipid. Six healthy subjects were studied after infusion of 20% lipid only. During infusions, changes in gastric volume were assessed and the proximal stomach was distended in steps of 1 mm Hg/min while symptoms were monitored and plasma CCK levels determined. In study B, 12 patients were studied twice to investigate the effect of CCK-A receptor blockade with dexloxiglumide on the symptomatic and gastric volume responses evoked by duodenal infusion of 20% lipid and gastric distension. VAS, visual analogue scale.