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. 2001 Mar;48(3):418–424. doi: 10.1136/gut.48.3.418

Figure 1  .

Figure 1  

Figure 1  

DNA fragmentation and Ki67 expression in coeliac disease (CD) and control intestine. (A) DNA fragmentation in enterocytes of CD and control intestine. (B) Expression of Ki67 in crypt enterocytes of CD and control intestine (mean (SD)). Untreated CD, untreated biopsies with patchy mucosal lesions (n=20); treated CD, treated biopsies (n=14); controls, biopsies from non-coeliac patients with a normal villus architecture (n=15). ***p<0.0001 v treated CD and controls. (C) Pattern of intraepithelial DNA fragmentation in untreated CD duodenum. DNA fragmentation (TUNEL technique, red colour) is absent in the nucleus of all intraepithelial lymphocytes (CD3, green colour), while it is detected in the majority of enterocytes. Original magnification ×240. Two colour immunofluorescence: TUNEL technique, RPE labelling (red); immunohistochemistry, CD3 labelling (green) (see methods).