Figure 2.
Chronic colitis model induced by TNBS: effect of resveratrol on colon injury. Histological appearance of rat colonic mucosa after haematoxylin and eosin stain (e–h) or Alcian blue stain (a, b): sham (a, b), and treated with TNBS 30 mg per animal (c, d), and resveratrol 10 mg kg−1 (e, f). Histopathological features of the colon in association with colitis. (a, b) No histological modification was present in the sham animals. (c, d) Mucosal injury was produced after TNBS administration, characterised by necrosis, oedema and higher fibrosis. (e) Treatment with resveratrol (10 mg kg−1) reduced the morphological alteration associated with TNBS administration protecting the mucosal architecture. (f) Some areas showed accumulation of mucus and cell remnants however, Alcian-blue-positive cells were less numerous, and the mucin layer of the epithelium was missing. Original magnification × 10.