Table 2.

Prostaglandin E₂ (pg mg⁻¹ tissue) and D₂ (pg mg⁻¹ tissue) after resveratrol administration (10 mg kg⁻¹) in rats with chronic colitis produced by TNBS intracolonic instillation (30 mg per animal)

Group	n	PGE2 (pg mg−1 tissue)	n	PGD2 (pg mg−1 tissue)
Sham	10	826.3±78.4	8	803.6±18.6
EtOH	6	622.9±111.3	6	899.5±42.2
TNBS	10	444.8±98.38a	8	1113.7±90.1a
TNBS+R 10	11	1090.9±145.7b	9	983.0±72.9

n: number of animals per group.

Prostanoids synthesis in the colonic tissue was quantified in the absence of treatment, but with daily administration of the vehicle saline solution (sham group, trinitrobenzene sulphonic acid group and ethanol group), or in the presence of resveratrol (R: 10 mg kg⁻¹ day⁻¹). Data are expressed as the mean±s.e.m. The synthesis of prostanoids were quantified as described in Methods and are expressed as pg mg⁻¹ tissue.

^aP<0.05 significantly different from sham.

^bP<0.001 significantly different from TNBS.