Table 1.
Impact of the pharmacological agents on the myogenic tone of the gracilis artery isolated from 3, 12 and 20 m/o WT and DL mice
| Conditions | WT | DL | ||||
|---|---|---|---|---|---|---|
| 3 m/o | 12 m/o | 20 m/o | 3 m/o | 12 m/o | 20 m/o | |
| Myogenic tone (control conditions) | 14±6 (6) | 32±6† (6) | 22±7 (5) | 6±3 (6) | 27±8 (8) | 30±11† (5) |
| INDO+L-NNA | 7±1 (7) | 29±6† (6) | 19±6 (5) | 6±2 (7) | 28±8† (6) | 31±10† (5) |
| +Apamin+Chtx | 26±7* (7) | 57±6*† (6) | 36±16 (3) | 30±12* (5) | 74±10*† (4) | 77±6*† (4) |
| +17-ODYA | 23±9 (4) | 28±6 (7) | 33±16 (3) | 15±10 (6) | 45±11 (6) | 55±8† (5) |
| +Ouabain | 55±14* (4) | 55±11* (6) | 36±28 (3) | 72±9* (7) | 70±5* (6) | 63±3* (4) |
Data are expressed as mean±s.e.m. All solutions contained INDO (10 μM) and L-NNA (100 μM), except in control conditions.
*
P<0.05 compared to INDO+L-NNA.
†
P<0.05 compared to 3 m/o.