Effects of naltrindole (NAL, 1 or 5 mg kg−1; (a, b) and the combination of SNC80 (5 mg kg−1) and naltrindole (1 and 5 mg kg−1) (c, d) on ambulatory activity. Ambulatory activity over time (a, c) and the activity during the 10 min period between 60–70 min postinjection (b, d) are shown. Data are expressed as the mean±s.e.m. (n=20 for saline group and n=8 for all other groups). **P<0.01 and ***P<0.001.