Table 2. Antidepressants – inhibition of human serotonin (SERT), norepinephrine (NET) and dopamine (DAT) transporters.

Generic name	Human SERT Kd (nM)	Human NET Kd (nM)	Human DAT Kd (nM)	Selectivity-SERT vs NET
Amitriptyline	4.3	35	3250	8
Amoxepine	58	16	4310	0.3
Bupropion	9100	52,000	520	5.7
Citalopram	1.2	4070	28,100	3500
Clomipramine	0.3	38	2190	130
Desipramine	17.6	0.8	3190	0.05
Dothiepin	8.6	46	5310	5.3
Doxepine	68	29.5	12,100	0.4
Fluoxetine	0.8	240	3600	300
Fluvoxamine	2.2	1300	9200	580
Imipramine	1.4	37	8500	27
Lofepramine	70	5.4	18,000	0.08
Maprotiline	5800	11.1	1000	0.002
Mirtazapine	>100,000	4600	>100,000	—
Nefazodone	200	360	360	1.8
Nortriptyline	18	4.4	1140	0.24
Paroxetine	.13	40	490	300
Protriptyline	19.6	1.4	2100	0.07
Reboxetine*	129	1.1	—	0.008
Sertraline	0.29	420	25	1400
Trazodone	160	8500	7400	53
Trimipramine	149	2450	780	16
Venlafaxine	8.9	1060	9300	120

Data from Tatsumi et al. (1997) and ^*Wong et al. (2000). The results are equilibrium dissociation constants (K_d) in nM, using [³H]-imipramine binding to human SERT, [³H]-nisoxetine binding to human noradrenaline transporter, and ³H-WIN35428 binding to human dopamine transporter (Tatsumi et al., 1997), or for reboxetine ^*(Wong et al., 2000) [³H]-citalopram binding to human SERT and [³H]-nisoxetine binding to the human NET. The most selective drugs are highlighted in bold in the right hand column.