Table 2. Disease targets for isoenzyme selective PDE inhibitors.

PDE family	Drug targets
2	Sepsis, Acute Respiratory Distress Syndrome (ARDS)
3	Airways disease, fertility
4	Allergic Rhinitis, Psoriasis, Multiple Sclerosis, Depression, Alzheimer's Disease, Schizophrenia, Memory loss, Cancer, Dermatitis
5	Pulmonary hypertension, female sexual dysfunction, cardiovascular disease, premature ejaculation, stroke, leukaemia, renal failure
7	Inflammation