Table 1. Human chemokines identified to date.
Systematic name | Colloquial name | Receptor usage | Systematic name | Colloquial name | Receptor usage |
---|---|---|---|---|---|
CCL1 | I-309 | CCR8 | CXCL1 | GROα/MGSA-α | CXCR2 |
CCL2 | MCP-1/MCAF | CCR2 | CXCL2 | GROβ/MGSA-β | CXCR2 |
CCL3 | MIP-1α/LD78α | CCR1, 5 | CXCL3 | GROγ/MGSA-γ | CXCR2 |
CCL3L1 | LD78β | CCR1, 5 | CXCL4 | PF-4 | CXCR3B |
CCL4 | MIP-1β | CCR5 | CXCL5 | ENA-78 | CXCR2 |
CCL4L1 | LAG-1 | CCR5 | CXCL6 | GCP-2 | CXCR1, 2 |
CCL5 | RANTES | CCR1, 3, 5 | CXCL7 | NAP-2 | CXCR2 |
CCL7 | MCP-3 | CCR1, 2, 3 (CCR5) | CXCL8 | IL-8 | CXCR1, 2 |
CCL8 | MCP-2 | CCR3 | CXCL9 | Mig | CXCR3 (CCR3) |
CCL11 | Eotaxin | CCR3 (CCR2) | CXCL10 | IP-10 | CXCR3 (CCR3) |
CCL13 | MCP-4 | CCR2, 3 | CXCL11 | I-TAC | CXCR3 (CCR3) |
CCL14 | HCC-1 | CCR1 | CXCL12 | SDF-1α/β | CXCR4 |
CCL15 | HCC-2/Lkn-1/MIP-1δ/MIP5 | CCR1, 3 | CXCL13 | BLC/BCA-1 | CXCR5 |
CCL16 | HCC-4/LEC | CCR1 | CXCL14 | BRAK/Bolekine | |
CCL17 | TARC | CCR4 | CXCL16 | SR-PSOX | CXCR6 |
CCL18 | DC-CK-1/AMAC-1/MIP5/ PARC/MIP-4 | CCR3 | |||
CCL19 | MIP-3β/ELC/Exodus-3 | CCR7 | XCL1 | Lymphotactin/ SCM-1α/ATAC | XCR1 |
CCL20 | MIP3α/LARC/Exodus-1 | CCR6 | XCL2 | SCM-1β | XCR1 |
CCL21 | SLC/6Ckine/Exodus-2 | CCR7 | |||
CCL22 | MDC/STCP-1 | CCR4 | CX3CL1 | Fractalkine, neurotactin | CX3CR1 |
CCL23 | MPIF-1 | CCR1 | |||
CCL24 | MPIF-2/Eotaxin-2 | CCR3 | |||
CCL25 | TECK | CCR9 | |||
CCL26 | Eotaxin-3 | CCR3, (CCR1, 2, 5) | |||
CCL27 | CTACK/ALP/ILC/ESkine | CCR10 | |||
CCL28 | MEC | CCR10, 3 |
The systematic names together with the colloquial names and receptor agonist activity are shown. Antagonist activity at other chemokine receptors is shown within parenthesis. Some human chemokines appear to be missing from the list, for example, CCL6. In such instances, while a chemokine of that name has been identified in the mouse, no human orthologue has been documented.
6ckine=chemokine with 6 cysteines; ALP=amino-terminal alanine-leucine-proline chemokine; AMAC=alternative macrophage activation-associated CC chemokine; ATAC=activation-induced, chemokine-related molecule; BCA=B-cell-attracting chemokine; BRAK=breast- and kidney-expressed chemokine; CTACK; cutaneous T-cell-activating chemokine; DARC=Duffy antigen receptor for chemokines; DC-CK1=dendritic cell-derived CC chemokine; ELC=EBL-1 ligand chemokine; ENA-78=epithelial neutrophil activating peptide 78; ESkine=embryonal stem cell chemokine; GCP=granulocyte chemotactic protein; GRO=growth-regulated oncogene; HCC=human CC chemokine; ILC=IL-11 receptor α-locus chemokine; IP, IFNγ-inducible protein; I-TAC=IFNγ-inducible T-cell chemoattractant; LAG=lymphocyte activation gene-1; LARC=liver- and activation-regulated chemokine; LEC=liver-expressed chemokine; Lkn=leukotactin; MCP=monocyte chemoattractant protein; MCAF=monocyte chemotactic and activating factor; MDC=monocyte-derived chemokine; MEC=mucosae-associated epithelial chemokine; MGSA=melanoma growth stimulatory activity; Mig=monokine-induced by IFNγ; MIP=macrophage inflammatory protein; MPIF=myeloid progenitor inhibitory factor; NAP=neutrophil-activating peptide; PARC=pulmonary- and activation-regulated chemokine; PF=platelet factor; RANTES=regulated on activation, normal T-cells expressed and secreted; SCM=single C motif; SDF-1=stromal cell-derived factor 1; SLC=secondary lymphoid tissue chemokine; SR-PSOX=scavenger receptor for phosphatidylserine and oxidized lipoprotein; STCP=stimulated T-cell chemoattractant protein; TARC=thymus- and activation-regulated chemokine; TECK=thymus-expressed chemokine.