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. 1989 Jul;33(7):1125–1127. doi: 10.1128/aac.33.7.1125

Treatment of Clostridium difficile-associated disease with teicoplanin.

F de Lalla 1, G Privitera 1, E Rinaldi 1, G Ortisi 1, D Santoro 1, G Rizzardini 1
PMCID: PMC176077  PMID: 2528941

Abstract

Forty-seven patients affected by Clostridium difficile-associated disease were treated orally with either vancomycin (patients hospitalized from February 1984 to February 1987) or teicoplanin (from March 1987 to December 1988). All patients given teicoplanin remained asymptomatic after discontinuation of treatment, and all but one were also cleared of C. difficile. In the vancomycin group, clinical symptoms recurred in 3 of 23 evaluable patients, and follow-up cultures were positive in another asymptomatic case.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aronsson B., Möllby R., Nord C. E. Antimicrobial agents and Clostridium difficile in acute enteric disease: epidemiological data from Sweden, 1980-1982. J Infect Dis. 1985 Mar;151(3):476–481. doi: 10.1093/infdis/151.3.476. [DOI] [PubMed] [Google Scholar]
  2. Aronsson B., Möllby R., Nord C. E. Diagnosis and epidemiology of Clostridium difficile enterocolitis in Sweden. J Antimicrob Chemother. 1984 Dec;14 (Suppl 500):85–95. doi: 10.1093/jac/14.suppl_d.85. [DOI] [PubMed] [Google Scholar]
  3. Bartlett J. G., Taylor N. S., Chang T., Dzink J. Clinical and laboratory observations in Clostridium difficile colitis. Am J Clin Nutr. 1980 Nov;33(11 Suppl):2521–2526. doi: 10.1093/ajcn/33.11.2521. [DOI] [PubMed] [Google Scholar]
  4. Bartlett J. G., Tedesco F. J., Shull S., Lowe B., Chang T. Symptomatic relapse after oral vancomycin therapy of antibiotic-associated pseudomembranous colitis. Gastroenterology. 1980 Mar;78(3):431–434. [PubMed] [Google Scholar]
  5. Bender B. S., Bennett R., Laughon B. E., Greenough W. B., 3rd, Gaydos C., Sears S. D., Forman M. S., Bartlett J. G. Is Clostridium difficile endemic in chronic-care facilities? Lancet. 1986 Jul 5;2(8497):11–13. doi: 10.1016/s0140-6736(86)92559-6. [DOI] [PubMed] [Google Scholar]
  6. Brazier J. S., Levett P. N., Stannard A. J., Phillips K. D., Willis A. T. Antibiotic susceptibility of clinical isolates of clostridia. J Antimicrob Chemother. 1985 Feb;15(2):181–185. doi: 10.1093/jac/15.2.181. [DOI] [PubMed] [Google Scholar]
  7. Buchanan A. G. Selective enrichment broth culture for detection of Clostridium difficile and associated cytotoxin. J Clin Microbiol. 1984 Jul;20(1):74–76. doi: 10.1128/jcm.20.1.74-76.1984. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Cherry R. D., Portnoy D., Jabbari M., Daly D. S., Kinnear D. G., Goresky C. A. Metronidazole: an alternate therapy for antibiotic-associated colitis. Gastroenterology. 1982 May;82(5 Pt 1):849–851. [PubMed] [Google Scholar]
  9. Church J. M., Fazio V. W. A role for colonic stasis in the pathogenesis of disease related to Clostridium difficile. Dis Colon Rectum. 1986 Dec;29(12):804–809. doi: 10.1007/BF02555349. [DOI] [PubMed] [Google Scholar]
  10. Cumming A. D., Thomson B. J., Sharp J., Poxton I. R., Fraser A. Diarrhoea due to Clostridium difficile associated with antibiotic treatment in patients receiving dialysis: the role of cross infection. Br Med J (Clin Res Ed) 1986 Jan 25;292(6515):238–239. doi: 10.1136/bmj.292.6515.238. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Fekety R. Recent advances in management of bacterial diarrhea. Rev Infect Dis. 1983 Mar-Apr;5(2):246–257. doi: 10.1093/clinids/5.2.246. [DOI] [PubMed] [Google Scholar]
  12. Fekety R., Silva J., Buggy B., Deery H. G. Treatment of antibiotic-associated colitis with vancomycin. J Antimicrob Chemother. 1984 Dec;14 (Suppl 500):97–102. doi: 10.1093/jac/14.suppl_d.97. [DOI] [PubMed] [Google Scholar]
  13. Fekety R., Silva J., Toshniwal R., Allo M., Armstrong J., Browne R., Ebright J., Rifkin G. Antibiotic-associated colitis: effects of antibiotics on Clostridium difficile and the disease in hamsters. Rev Infect Dis. 1979 Mar-Apr;1(2):386–397. doi: 10.1093/clinids/1.2.386. [DOI] [PubMed] [Google Scholar]
  14. George R. H. The carrier state: Clostridium difficile. J Antimicrob Chemother. 1986 Jul;18 (Suppl A):47–58. doi: 10.1093/jac/18.supplement_a.47. [DOI] [PubMed] [Google Scholar]
  15. George W. L. Antimicrobial agent-associated colitis and diarrhea: historical background and clinical aspects. Rev Infect Dis. 1984 Mar-Apr;6 (Suppl 1):S208–S213. doi: 10.1093/clinids/6.supplement_1.s208. [DOI] [PubMed] [Google Scholar]
  16. George W. L., Rolfe R. D., Finegold S. M. Clostridium difficile and its cytotoxin in feces of patients with antimicrobial agent-associated diarrhea and miscellaneous conditions. J Clin Microbiol. 1982 Jun;15(6):1049–1053. doi: 10.1128/jcm.15.6.1049-1053.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Keighley M. R., Burdon D. W., Arabi Y., Williams J. A., Thompson H., Youngs D., Johnson M., Bentley S., George R. H., Mogg G. A. Randomised controlled trial of vancomycin for pseudomembranous colitis and postoperative diarrhoea. Br Med J. 1978 Dec 16;2(6153):1667–1669. doi: 10.1136/bmj.2.6153.1667. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Kleinfeld D. I., Sharpe R. J., Donta S. T. Parenteral therapy for antibiotic-associated pseudomembranous colitis. J Infect Dis. 1988 Feb;157(2):389–389. doi: 10.1093/infdis/157.2.389. [DOI] [PubMed] [Google Scholar]
  19. Malamou-Ladas H., O'Farrell S., Nash J. Q., Tabaqchali S. Isolation of Clostridium difficile from patients and the environment of hospital wards. J Clin Pathol. 1983 Jan;36(1):88–92. doi: 10.1136/jcp.36.1.88. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Newsom S. W., Matthews J., Rampling A. M. Susceptibility of Clostridium difficile strains to new antibiotics: quinolones, efrotomycin, teicoplanin and imipenem. J Antimicrob Chemother. 1985 May;15(5):648–649. doi: 10.1093/jac/15.5.648-a. [DOI] [PubMed] [Google Scholar]
  21. Pantosti A., Luzzi I., Cardines R., Gianfrilli P. Comparison of the in vitro activities of teicoplanin and vancomycin against Clostridium difficile and their interactions with cholestyramine. Antimicrob Agents Chemother. 1985 Dec;28(6):847–848. doi: 10.1128/aac.28.6.847. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. Silva J., Jr, Batts D. H., Fekety R., Plouffe J. F., Rifkin G. D., Baird I. Treatment of Clostridium difficile colitis and diarrhea with vancomycin. Am J Med. 1981 Nov;71(5):815–822. doi: 10.1016/0002-9343(81)90369-7. [DOI] [PubMed] [Google Scholar]
  23. Sutter V. L., Barry A. L., Wilkins T. D., Zabransky R. J. Collaborative evaluation of a proposed reference dilution method of susceptibility testing of anaerobic bacteria. Antimicrob Agents Chemother. 1979 Oct;16(4):495–502. doi: 10.1128/aac.16.4.495. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Talbot R. W., Walker R. C., Beart R. W., Jr Changing epidemiology, diagnosis, and treatment of Clostridium difficile toxin-associated colitis. Br J Surg. 1986 Jun;73(6):457–460. doi: 10.1002/bjs.1800730614. [DOI] [PubMed] [Google Scholar]
  25. Teasley D. G., Gerding D. N., Olson M. M., Peterson L. R., Gebhard R. L., Schwartz M. J., Lee J. T., Jr Prospective randomised trial of metronidazole versus vancomycin for Clostridium-difficile-associated diarrhoea and colitis. Lancet. 1983 Nov 5;2(8358):1043–1046. doi: 10.1016/s0140-6736(83)91036-x. [DOI] [PubMed] [Google Scholar]
  26. Tedesco F., Markham R., Gurwith M., Christie D., Bartlett J. G. Oral vancomycin for antibiotic-associated pseudomembranous colitis. Lancet. 1978 Jul 29;2(8083):226–228. doi: 10.1016/s0140-6736(78)91741-5. [DOI] [PubMed] [Google Scholar]
  27. Young G. P., Ward P. B., Bayley N., Gordon D., Higgins G., Trapani J. A., McDonald M. I., Labrooy J., Hecker R. Antibiotic-associated colitis due to Clostridium difficile: double-blind comparison of vancomycin with bacitracin. Gastroenterology. 1985 Nov;89(5):1038–1045. doi: 10.1016/0016-5085(85)90206-9. [DOI] [PubMed] [Google Scholar]
  28. de Lalla F., Santoro D., Rinaldi E., Suter F., Cruciani M., Guaglianone M. H., Rizzardini G., Pellegata G. Teicoplanin in the treatment of infections by staphylococci, Clostridium difficile and other gram-positive bacteria. J Antimicrob Chemother. 1989 Jan;23(1):131–142. doi: 10.1093/jac/23.1.131. [DOI] [PubMed] [Google Scholar]

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