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A schematic representation of HIV-1 gp160. gp160 is proteolytically processed into the receptor-binding domain, gp120 (green), and the transmembrane domain gp41—composed of an ectodomain (red), transmembrane helix (TM, black), and cytoplasmic domain (blue). The cytoplasmic domain contains two palmitoylated cysteine residues at positions 764 and 837 (22). The location of the gp160 mAb (Chessie-8) recognition sequence (PDRPEG) is indicated (27).
