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. 2007 Jan 5;3(1):e4. doi: 10.1371/journal.pcbi.0030004

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© 2007 Kumar et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) A scores plot identifies separation in signaling strategies associated with receptor overexpression or differential ligand treatment along two signaling axes.

(B) HRG and EGF treatment give rise to different sets of signals, and the difference is exaggerated in 24H cells.

(C) The linear superposition of the difference vector between 24H and parental serum-free conditions and each ligand's vector explains 24H + HRG signaling but not 24H + EGF signaling.