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Cleavage of break light A by calicheamicin and esperamicin. The observed DNA cleavage over time of an assay containing 3.2 nM break light A at 37°C (40 mM Tris⋅HCl, pH 7.5; λEx = 485 nm, λEm = 517 nM), DTT (50 μM) and varied enediyne. (a) Calicheamicin concentrations: 31.7 nM (○), 15.9 nM (□), 3.2 nM (⋄), 1.6 nM (▵), 0.78 nM (●), and 0.31 nM (■). (b) Esperamicin concentrations: 31.7 nM (○), 15.9 nM (□), 3.2 nM (⋄), 1.6 nM (▵), 0.78 nM (●), 0.31 nM (■), and 0.15 nM (♦).
