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. Author manuscript; available in PMC: 2007 Jan 2.
Published in final edited form as: Trends Cell Biol. 2005 Aug;15(8):414–424. doi: 10.1016/j.tcb.2005.06.007

Figure 3.

Figure 3

Schematic depiction of septin recruitment and septin-collar formation during the cell cycle of budding yeast. Recruitment of either a patch or cap of septins to the incipient bud site and its rapid conversion into a rimmed disk require the small GTPase, Cdc42. Stabilization of the disk and its transformation into a filamentous collar requires phosphorylation by two proteins kinases, Cla4 and Gin4 (and, perhaps, others), plus binding of GTP to Cdc10 and Cdc12 in the septin complex. At cytokinesis, the collar splits into two separate rings, which are disassembled after cell separation. Confocal fluorescence images (GFP–Cdc12) were kindly provided by Jeroen Dobbelaere (ETH, Zürich, Switzerland).