Growth defect in p/CIP(−/−) mice. (A) Embryonic
(E15.5) difference of wild-type and p/CIP(−/− mice in size.
(B) Weight difference of postnatal day 1 in wild-type,
heterozygous, and p/CIP(−/−) mice. **,
P < 0.01. (C) Rates of growth in
wild-type, heterozygous, and p/CIP(−/−) mice. (D)
Expression of GH using in situ analysis on adult
pituitary gland. (E) Harris hematoxylin whole-mount
staining of mammary glands of 10-week-old female virgin littermates
from wild-type and p/CIP(−/−) mice (lymph node, LN); no
reproducible differences were observed at any developmental stages.