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. Author manuscript; available in PMC: 2007 Dec 13.
Published in final edited form as: Brain Res. 2006 Nov 16;1125(1):46–59. doi: 10.1016/j.brainres.2006.09.090

Table 4.

Baroreflex response before and after GABA receptor blockade in the RVLM

Control RVLM GABA Receptor Blockade
Δ MAP (mm Hg) Δ RSNA (% C) Δ RSNA/Δ MAP Δ MAP (mm Hg) Δ RSNA (% C) Δ RSNA/Δ MAP
Protocol 1 (n=7) 37.5 ± 5 −61 ± 8.1 −1.8 ± 0.25 34 ± 4.1 −1.3 ± 1.2* −0.04 ± 0.04*
Protocol 2 (n=8) 40 ± 4.3 −55 ± 10.5 −1.4± 0.2 30 ± 2.2 −5 ± 2.4* −0.15 ± .08 *

In right NTS lesioned rats, phenylephrine (PE, 5 μg/kg, i.v.) increased MAP similarly before and after left RVLM Bicuculline (BIC) (Protocol 1) or BIC+CGP35348 (Protocol 2). Decreases in RSNA were reduced by left RVLM GABA receptor blockade. Estimated baroreflex gain (Δ RSNA/Δ MAP) was decreased by 98% with RVLM GABAA receptor block and by 89% with GABAA + GABAB receptor blockade. Values = mean ± SEM;

*

P ≤ 0.05 compared to corresponding control value.